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Article
May 1929

THE CHEMOTHERAPY AND SERUM THERAPY OF PNEUMOCOCCUS AND STREPTOCOCCUS MENINGITISVII. THE INTRACAROTID TREATMENT FOR EXPERIMENTAL PNEUMOCOCCUS MENINGITIS

Author Affiliations

Professor of Pathology and Bacteriology in the Graduate School of Medicine of the University of Pennsylvania and Member of the Research Institute of Cutaneous Medicine; PHILADELPHIA
From the Research Institute of Cutaneous Diseases of Philadelphia. Aided by the Tony Colket Memorial Fund for Investigation in Meningitis.

Arch Otolaryngol. 1929;9(5):509-527. doi:10.1001/archotol.1929.00620030535004
Abstract

The great difficulty and indeed the impossibility of bringing medicaments in contact with all of the meninges infected in severe septic meningitis by cerebral cisternal spinal lavage and medication, especially when the subarachnoid exudates have become plastic,1 has led me to try the treatment for pneumococcus meningitis produced in dogs by injections of antipneumococcus agents into both common carotid arteries. Injections of dyes have shown an intense and widely distributed concentration of inoculum in the cerebral and basilar meninges, reaching as far as the upper end of the cord, with the passage of a portion into the cerebrospinal fluid.

Furthermore, the ease and safety with which Hirsch, Myerson and Halloran2 and others have given intracarotid injections of neoarsphenamine and sulpharsphenamine in the treatment for paresis have shown that this route of medication might be used with safety in human beings if encouragement were found in

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