Polypoid degeneration of the mucosa of the nose and accessory sinuses is a pathologic process frequently encountered and difficult to deal with. The results of medical treatment and surgical measures are often discouraging to both the patient and the physician. The etiology of polypoid sinusitis is not well understood. The condition is usually, but not always, associated with a suppurative sinusitis. Skillern stated that repeated attacks of coryza, each one leaving greater changes in the mucosa, contribute to the ultimate formation of polypoid tissue. Influenza seems to be a predisposing factor. Hyperemia of the tissues with a continued exudation of serum into the interstitial spaces, plus the force of gravity, tends to produce mucous polypi. Round cell and leukocytic infiltration in the mucosa, edema of the connective tissue, hypertrophy of the mucous glands, thickening of the periosteum and, finally, bone absorption describe briefly the pathologic picture.
ROBINSON GA. THE TREATMENT OF POLYPOID SINUSITIS. Arch Otolaryngol. 1929;10(1):72–73. doi:10.1001/archotol.1929.00620040082009
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