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August 1929


Author Affiliations

From the Department of Otolaryngology, Stanford University School of Medicine.

Arch Otolaryngol. 1929;10(2):189-190. doi:10.1001/archotol.1929.00620050085008

There is an important field of usefulness in rhinology for drugs which reduce the swelling of congested or inflamed mucous membranes. Agents which constrict the blood vessels and reduce the turgescence of the mucosae thereby facilitate examination of the nose and improve its drainage. The use of ephedrine in this connection has recently been advocated, its principal advantage appearing to be that its solutions are stable (unlike epinephrine) and that it is not a narcotic (unlike cocaine). This compound, however, produces considerable irritation and swelling in susceptible patients and is, moreover, unduly expensive. A compound which appeared more promising than ephedrine was recently introduced by Miller and Piness1 and Alles2 under its chemical name, phenylamino-ethanol sulphate. The pharmacologic studies by Alles and by Tainter3 showed that it constricted vessels by direct muscular stimulation similarly to ephedrine and was also stable in solution. We have therefore tested the

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