Investigation of the sphenoid sinus is probably more difficult than the study of the other nasal accessory sinuses. This is due to its deep position and to the frequent anatomic obstructions within the nose that prevent its satisfactory exploration. With a clinical history and local physical observations in the nose and throat directing the attention to the posterior group of sinuses, several valuable aids may be employed to establish a diagnosis of sphenoiditis. X-ray studies alone or following the injection of iodized oil give helpful information in diagnosis. A cytologic study of the secretion contained within the sinus is given as an additional valuable method in proving or eliminating the presence of trouble in the sphenoid.
From the x-ray picture one may be able to demonstrate thickening of the mucous membrane, the presence of polypi and, in some cases, the presence of a fluid level of secretion contained within
TILLOTSON RS. SPHENOIDITIS: VALUE OF CYTOLOGIC STUDIES IN DIAGNOSIS. Arch Otolaryngol. 1929;10(3):262–265. doi:10.1001/archotol.1929.00620060058005
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