According to Eggston, from a histologic point of view only 1 per cent of carcinomas of the larynx are papillary.
A review of the literature shows that carcinoma of the larynx may follow the premalignant stage of either syphilis or tuberculosis. Sir St. Clair Thompson said, "I do not think that a frank papilloma or fibroma of the larynx becomes malignant, but the manifestation of malignant disease is, in a certain number of cases, foreshadowed by some vocal defect." Jackson reported a case of papilloma of the larynx that was followed thirty years later by cancer, and another similar case in which the papilloma was followed by cancer eight years later. Mackenty recently reported a case of papillary carcinoma of the larynx in a woman, aged 20, who had hoarseness for three years. Neither Jackson nor Mackenty made any mention of antecedent pathologic conditions in their reports.
It would seem