In chronic nasal obstructive diseases it is frequently necessary to prescribe solutions of epinephrine and ephedrine over a period of time. This is particularly true in chronic conditions of the sinuses as well as in the various cases of vasomotor rhinitis encountered in ordinary practice. Whether or not these drugs, acting as a palliative in the beginning, are deleterious after long usage, is a matter deserving investigation.
In another paper,1 I report what appears histologically to be an injury to the nasal vasculosa of animals sprayed only once with a 1:1,000 solution of epinephrine, while no such injury is apparent in animals sprayed with a 1: 50 solution of ephedrine. The purpose of these experiments is to note the effect of these drugs on the nasal mucosa of rabbits after daily usage over a long period of time. A 1: 1,000 solution of epinephrine chloride and a 1: 50
FOX N. THE CHRONIC EFFECT OF EPINEPHRINE AND EPHEDRINE ON THE NASAL MUCOSA. Arch Otolaryngol. 1931;13(1):73–76. doi:10.1001/archotol.1931.03660010083008
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