Owing to the complicated anatomic structure and individual anomalies of the paranasal sinuses in relation to size, shape and location, the treatment for chronic sinusitis is frequently disappointing in spite of surgical drainage and topical applications.
In this connection, a rather large and controversial literature has accumulated on vaccine therapy for infections of the ear, nose, throat and paranasal sinuses, although the results have generally been unsatisfactory. Some investigators have reported encouraging results, while those of others have been unfavorable, so that the exact status of vaccine therapy for sinusitis is still unsettled. Doubtless, important factors in failure have been inadequate drainage and the too widespread use of stock vaccines or the use of poorly prepared autogenous ones with failure to secure in cultures the important organisms producing the infection.
Any new method of vaccine therapy offering hope of improving the results is therefore a matter of clinical importance. In
AMANO KW. PARANASAL SINUSITISLOCAL IMMUNIZATION TREATMENT. Arch Otolaryngol. 1931;14(1):30–35. doi:10.1001/archotol.1931.03580020038006
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