An outstanding contribution to the literature on devastating burns, which present so many problems in reparative surgery, is that made by Underhill1 and a group working on research at Yale. Attention is focused on the concentration of the blood following the loss of water from the body after burns. First there is the positive loss of fluid by permeation outward, the fluid being identified, through its coagulation on the surface, with the plasma which fills the interstices between the cells; next the capillaries are rendered unable to exercise the normal constraint on the passage of water from the arteries, and finally, the return vessels are inhibited from maintaining a supply of fluid to the blood stream, which therefore becomes concentrated with results that become disastrous after a certain degree of concentration of the blood has been attained. Studies reported in other of these reviews have been addressed to the
SHEEHAN JE. PLASTIC SURGERY. Arch Otolaryngol. 1931;14(3):377–379. doi:10.1001/archotol.1931.00630020417014
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