Some time ago we1 published an article on the effects of some drugs on the vestibular response to rotation. In our work very large doses of drugs were used, and the number of drugs was limited. Our conclusions were that nitrite, cocaine and pilocarpine reduced the reaction of the vestibular apparatus because of the general depression and not from any specific action. The large doses of epinephrine, nicotine and atropine produced no marked changes in reaction.
The specificity of various drugs discovered by the various investigators quoted in our previous communication has encouraged us to do further work. Moderate doses of drugs have been employed in the same manner as before. Just enough of the drug has been used to give definite signs of action. The manner of stimulation was by rotation of the animal in a vertical position, at a constant rate and for a definite period of
ROSS EL, FISH MW, OLSEN A. EFFECTS OF SOME DRUGS ON THE VESTIBULAR RESPONSE TO ROTATION. Arch Otolaryngol. 1931;14(6):755–774. doi:10.1001/archotol.1931.03580020846005
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