In 1888, Mikulicz1 reported before the Verein für wissenschaftliche Heilkunde a case of bilateral, chronic, painless enlargement of the lacrimal glands with an associated enlargement of the salivary glands in a man 42 years of age. As time passed, this disease came to bear the name of Mikulicz. This disorder, as first described by Mikulicz, consists of a chronic symmetrical enlargement of the lacrimal and salivary glands. The pulse and temperature remain normal. The general health is not impaired. The swelling is hard, painless and noninflammatory. The blood picture remains within normal limits. The remainder of the lymphatic structure is not involved. Mikulicz could discover no cause for this condition, but it was his opinion that it was due to some infection.
Since that time, more than one hundred similar cases have been reported. However, as our knowledge of this disease increased, it soon became evident that not all
DIXON FW. MIKULICZ' DISEASE AND SYNDROME. Arch Otolaryngol. 1932;15(3):438–441. doi:10.1001/archotol.1932.03570030456011
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: