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Article
January 1933

EFFECT OF SILVER NITRATE ON THE NASAL MUCOSA OF RABBITS

Author Affiliations

Fellow in Otolaryngology, the Mayo Foundation ROCHESTER,MINN.
From the Division of Experimental Surgery and Pathology and the Section on Otolaryngology and Rhinology, the Mayo Clinic.

Arch Otolaryngol. 1933;17(1):1-7. doi:10.1001/archotol.1933.03570050008001
Abstract

In the treatment of vasomotor rhinitis and other conditions characterized by hyperesthesia of the nasal mucous membranes, good clinical results are usually obtained by the injection of alcohol into the sphenopalatine ganglion and by the application of solutions of silver nitrate to the mucous membrane over this ganglion. Following the latter method of treatment, beneficial results may appear in from one to two weeks and last for a year.

In an attempt to determine why such benefit should result from local applications of silver nitrate, series of experiments were performed on rabbits, 20 per cent solution of silver nitrate being applied to the nasal mucosa. At varying intervals afterward, the animals were killed, and sections of the nasal mucous membrane, which had been treated, were studied histologically.

EXPERIMENTAL DATA

Rabbits, apparently, do not have a true sphenopalatine ganglion as does man. The nerve supply to the mucosa of

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