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OSLER'SDISEASEWITHNASALHEMORRHAGE (MULTIPLEHEREDITARYTELANGIECTASIS). DR. FRANK J. PISZKIEWICZ (by invitation).
This condition was first put on a clinical basis by Osler in an article in 1901 (Bull. Johns Hopkins Hosp. 12:330, 1901). It is a hereditary condition which is characterized by the formation of telangiectatic lesions on the mucous membranes of the mouth, nose and throat. Any mucous membrane of the body may be involved, although the disease commonly is characterized by severe epistaxis. Other hemorrhages may occur from other parts.
The diagnosis is simple, and is made by finding telangiectatic lesions in the mucous membranes,by a history of familial occurrence and by the fact that it is not limited to sex, as is hemophilia. It may be transmitted by both the male and the female of the species. Bleeding time and coagulation time are normal, although the condition has often been confused with
YOUNGER CB. CHICAGO LARYNGOLOGICAL AND OTOLOGICAL SOCIETY: Regular Meeting, Nov. 7, 1932. Arch Otolaryngol. 1933;17(3):429–441. doi:10.1001/archotol.1933.03570050417012
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