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THE BIOLOGIC EFFECT OF ROENTGEN AND RADIUM RAYS. DR. ENGLMANN.
The observations are based on a histopathologic diagnosis of the tumors reported and on the other (healthy) tissues studied.
After a destructive dose the changes in the tumor cells consist of vacuolation, droplet or mucoid degeneration, fatty or lime deposits in the protoplasm, with pyknotic or chromatolytic changes in the nuclei, and, rarely, amyloid changes.
The studies of the adjacent tissues were made after treatment according to the Coutard method, that is, frequently repeated small doses over a long period.
In a few cases there was a slight leukopenia, and 2 of 12 studied showed a slight increase in monocytes. Therefore there was no serious damage to the cellular elements of the blood stream.
The sebaceous and sudoriferous glands showed atrophic changes, but fewer than under the former intensive treatment.
The lymphatic tissues showed definite atrophy, but under the microscope
LEWY A. GERMAN OTOLARYNGOLOGICAL SOCIETY: Bad Elms, May 12 to 14, 1932: ZEITSCHRIFT FÜR HALS-, NASEN- UND OHRENHEILKUNDE 31:132, 1932. Arch Otolaryngol. 1933;17(4):597–615. doi:10.1001/archotol.1933.03570050587012
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