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Article
May 1933

EFFECT OF DESTRUCTION OF ONE LABYRINTH ON REACTIONS TO ROTATION

Arch Otolaryngol. 1933;17(5):684-692. doi:10.1001/archotol.1933.03570050675009
Abstract

The pharmacology of the vestibular apparatus has been the subject of our investigation for some time.1 The work up to the present has been done chiefly on normal dogs. In our last article2 the only recorded operative procedure consisted of sectioning the posterior columns of one side of the spinal cord in the occipital region. It is generally considered, anatomically, that the vestibular apparatus is divided into two equal asymmetrical parts. Since one side is often destroyed by injury or disease, it was deemed of interest to study the reactions to rotation after the destruction of one labyrinth. It was thought, also, that this condition might reveal to advantage the action of certain drugs.

EXPERIMENTAL WORK

Dogs were used as subjects. The animals were anesthetized for operation. An incision was made through the skin, back of the mastoid region. The muscular attachments below the nuchal ridge

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