Many studies on the pathology of the suprarenal glands have lent support to the theory advanced forty years ago that the suprarenal cortex detoxifies, probably by its lipids, not only metabolic products but also bacterial toxins, and also protects the organism against bacterial invasion. In 1889 Roux and Yersin,1 the discoverers of diphtheria toxin, observed marked hyperemia of the suprarenal cortex of the rabbit and the guinea-pig following the subcutaneous or intraperitoneal injection of diphtheria toxin. The following year Behring,2 in immunizing guinea-pigs against diphtheria toxin, found that the suprarenal cortex was always swollen and congested. Oppenheim and Loeper,3 in their experimental and clinical investigations on diphtheria, tetanus, anthrax and pneumonia, found necrosis of the cortical cells, hemorrhage and polymorphonuclear infiltration in the cortex. Bogolomez4 demonstrated that degenerative changes developed in the suprarenal cortices of cats given injections of diphtheria toxin alone,
WENNER WF. EFFECT OF EXTRACT OF THE SUPRARENAL CORTEX ON MAXILLARY SINUSITIS IN THE RABBIT. Arch Otolaryngol. 1933;17(6):774–782. doi:10.1001/archotol.1933.03570050766006
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