In a recent article in The Journal of the American Medical Association, Lichtenberg, Werner and Lueck1 questioned both the pathogenicity of the fusospirochetal organisms and the success of treatment with the arsenicals. After a number of years of experience with the disease in the laboratory and in the clinic, I have arrived at the conclusion diametrically opposed to that of Lichtenberg and his associates, that this group of anaerobic organisms has under certain conditions a primary pathogenicity, and that arsenical therapy is usually the most efficient treatment. In view of this difference of opinion, it seems advisable to review the evidence in favor of the pathogenicity of this group of organisms and to report some cases which illustrate the indications, dangers and limitations of arsenical therapy in fusospirochetal infections.
In 1894, Veillon2 observed in necrotic, foul lesions of the throat the following mixture of
SMITH DT. SHOULD FUSOSPIROCHETAL INFECTIONS BE TREATED WITH ARSENICALS? REPORT OF CASES. Arch Otolaryngol. 1933;18(6):760–769. doi:10.1001/archotol.1933.00630060820004
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: