In proving that cardiospasm is due to fibrosis of the terminal portion of the esophagus caused by infection from contiguous organs, Mosher1 found that these changes might also result from infection within the esophagus. He has found that acute infection arising within the esophagus occurs either as superficial ulceration or as edema of the submucosa and infiltration of the connective tissue, whereas chronic infection of the esophagus is shown by a generalized infiltration with small round lymphocytes and plasma cells and by an increase in the subepithelial connective tissue, or by an increase in the connective tissue throughout the esophagus and in the periesophageal structures. It has been shown that fibrosis of localized areas is fairly common, especially in chronic infections such as arteriosclerosis. In infections of the blood stream, the esophagus may be involved to the extent of ulceration. Infection of the esophagus may occur in acute diseases,
CLERF LH. PERORAL ENDOSCOPY. Arch Otolaryngol. 1934;19(2):253–271. doi:10.1001/archotol.1934.03790020099011
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