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Article
December 1934

AGRANULOCYTOSIS (MALIGNANT NEUTROPENIA)

Author Affiliations

PHILADELPHIA

Arch Otolaryngol. 1934;20(6):765-781. doi:10.1001/archotol.1934.03600060002001
Abstract

It is reasonable to believe that as man advances in civilization new diseases will arise in response to new environmental phenomena.

Most authorities agree that agranulocytosis, or malignant neutropenia, has not been described in past years because it is a comparatively recent disease. Although blood counts have been taken for more than fifty years in most hospitals, not one case of this condition was reported in these institutions.

A thorough review gives Senator1 the credit of the first report in the literature. In 1888, he reported four cases of an unusual type of pharyngitis, all resulting in death. The clinical picture closely followed malignant neutropenia. Pepper,2 in an excellent article on this subject, stated that Mackenzie3 gave Gubler,4 in 1857, and Trousseau,5 in 1865, credit for describing the symptomatology of this condition and differentiating it from other anginas, including diphtheria. It was, however, not until

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