SYNOPSIS OF EXPERIMENTS
During 1933 and 1934 our work was directed along several lines, using the cat's frontal sinus, in which chronic inflammation closely resembling human types of reaction had been produced by inoculation with human hemolytic streptococci. On completion of each experiment the animal was vital-stained with 1 per cent trypan blue, and the tissues, fixed in situ with formaldehyde-Zenker fluid, were counterstained with hematoxylin and eosin-azur. The technic followed, including the staining of human tissues with eosin-azur, was that used and reported in all the previous research of this series (1930 to 1933).The procedure was as follows: Each of a series of young cats of the same litter having unilateral chronic (of six weeks' duration) frontal sinusitis (1) was inoculated subcutaneously with 1 per cent peptone, (2) received from 1 to 2 cc. of 1 per cent peptone, injected into the sinus cavity by puncture with a
LARSELL O, FENTON RA. FURTHER RESEARCH ON EXPERIMENTAL AND CLINICAL SINUSITIS. Arch Otolaryngol. 1934;20(6):782–789. doi:10.1001/archotol.1934.03600060019002
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