The importance of the upper respiratory tract as a portal of entry for infectious agents is generally recognized, but information concerning the ways in which the agents induce local respiratory infection is meager and inconclusive. The frequent presence of pathogenic microorganisms in the nose and throat in the absence of actual disease indicates that these regions normally possess a considerable degree of resistance to the penetration of bacteria into the deeper tissues, and suggests the barrier action of mucus, cilia and epithelium. The conditions that tend to restrict the general spread of inflammatory agents throughout the body, however, are not so well understood, although the blood and lymphatic vessels, lymph nodules, macrophages, leukocytes and fluids of the tissues no doubt play an important part. In view of recent evidence indicating that antibodies in tissues may influence in large measure the immediate fixation of bacteria, perhaps more attention should be given
WALSH TE, CANNON PR. IMMUNIZATION OF THE UPPER RESPIRATORY TRACT. Arch Otolaryngol. 1934;20(6):820–836. doi:10.1001/archotol.1934.03600060057006
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