It is well known that the presence of Pneumococcus type III in acute mastoiditis offers a serious prognosis because of the frequency of subsequent intracranial complications. Inasmuch as these complications occur, as a rule, at least several weeks after the initial infection, attempts to induce a state of active acquired immunity should receive serious consideration. Prophylactic vaccination has been suggested by Kolmer and Amano1 on the basis of their work with rabbits in which immunization with pneumococcus vaccines afforded protection against experimental meningitis. Barach2 demonstrated that type-specific active immunity was acquired within six days after intradermal or intravenous injection of pneumococcus type-heterologous vaccines in cases of lobar pneumonia. Accordingly, in September 1931, a study was undertaken to determine the efficacy of immunization against intracranial infections in cases of mastoiditis due to infection with Pneumococcus type III. To accomplish this, every patient admitted to the otologic service of
GOLDMAN JL, SHWARTZMAN G, HERSCHBERGER C. PROPHYLACTIC VACCINATION AGAINST INTRACRANIAL COMPLICATIONS FOLLOWING PNEUMOCOCCUS TYPE III MASTOIDITIS. Arch Otolaryngol. 1935;21(2):154–156. doi:10.1001/archotol.1935.00640020163004
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