We realize full well the difficulties encountered when one is called on to prescribe treatment for malignant disease in the region of the tonsil, hypopharynx or larynx. Likewise we are aware that treatment in any form thus far developed has proved inadequate in a lamentably high percentage of cases.
In reviewing the list of remedies available, we find that it consists of surgical removal, destruction by heat, destruction by irradiation or a combination of surgical removal and irradiation.
The treatment of this type of disease is attended by difficulties peculiar to the region in which it is located in that the neoplasm, because of its inaccessibility, is not readily visible and therefore is usually seen in a late stage. Even when it is seen early, the tendency of this type of tumor to metastasize early and the fact that the lymphatics are practically always involved further render a successful
ARBUCKLE MF, COWDRY EV, VOTAW R. EFFECT OF RADIUM EMANATIONS ON THE LARYNGEAL CARTILAGE. Arch Otolaryngol. 1935;21(3):249–264. doi:10.1001/archotol.1935.00640020259001
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