The occurrence of isolated tumor-like deposits of amyloid in such areas as the upper air passages may have a variable significance depending on associated pathologic conditions in the body as well as on the presence or absence of a basic etiologic factor. The following classification into four groups is based on an analysis of published reports of cases in the literature:
1. Local amyloid deposits occurring secondarily within neoplasms or areas of chronic inflammation. This type should be distinguished from primary local amyloid tumors which have no obvious basis in preexisting changes of the tissue. Secondary amyloid tumors are well known and have been reported frequently, especially in fibromas and sarcomas (Martuscelli). Peroni described amyloid infiltration also in inflammatory polypi of the larynx and the ear.
2. Local tumor-like amyloid deposits which are part of a generalized amyloidosis of the usual type involving liver, spleen, kidneys and suprarenal
KRAMER R, SOM ML. LOCAL TUMOR-LIKE DEPOSITS OF AMYLOID IN THE LARYNX: REPORT OF A CASE WITH A REVIEW OF THE LITERATURE. Arch Otolaryngol. 1935;21(3):324–334. doi:10.1001/archotol.1935.00640020334008
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