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May 1935


Author Affiliations

From the Mosher Laboratory, Massachusetts Eye and Ear Infirmary.

Arch Otolaryngol. 1935;21(5):507-514. doi:10.1001/archotol.1935.00640020521001

There is no question of the vast amount of good done and the remarkable cures effected by radium when used therapeutically, but the fact should be emphasized that there is another side to the question and that frequently instead of a cure a burn results, which in many instances is worse than the original lesion. Few physicians who refer patients for radium therapy know what the ultimate outcome is, so far as changes in the tissues are concerned.

It is my purpose in this paper to point out the pathologic changes in the tissues by which radium burns are brought about. Very small doses of radium were used so that the changes noted would be gradual and thus they could be more carefully studied and the steps in the pathologic changes from engorgement and dilatation of the vessels to thrombosis and necrosis could be seen.

The stages in the development

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