In 1932 I1 described a reaction, specific in nature, which occurs with each electrosurgical treatment of an infected focus. Subsequent observations have brought to light a rational explanation for the "immunity reaction" which follows electrocoagulation. In order that a scientific appraisal of this so-called "autogenous vaccine reaction" may be made, an analysis of the reaction in 100 patients on whom electrosurgical tonsillectomy was performed has been undertaken.
The throat of each patient was swabbed and the predominant organism isolated by smear and culture at the initial treatment. A measured dose of electrocoagulation, desiccation and fulguration was given each patient at each weekly sitting. The time at which the reaction occurred, its duration, type and severity, whether local or general in scope, were noted and recorded in each case.
It has been apparent for some time that patients responded with a marked degree of variation in the
SILVERS LJ. THE IMMUNOLOGIC ASPECT OF ELECTROSURGERY IN RHINOLARYNGOLOGY. Arch Otolaryngol. 1935;21(5):527–535. doi:10.1001/archotol.1935.00640020541003
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