The obliterating action of various chemicals when injected into veins has been known since the invention of the hypodermic syringe in 1851 by Pravaz. The use of drugs as therapeutic agents for injection into varicose veins of the leg was not practiced to any great extent until about fifteen years ago when Linser,1 in Germany, reported the use of corrosive mercuric chloride and later of strong solutions of sodium chloride for this purpose. The use of solutions of quinine was first recorded by Genevrier2 in France. Sicard, Paraf and Lermoyez3 reported the use of aqueous solutions of sodium salicylate and Sicard and Gaugier4 the results of a series of 325,000 injections without pulmonary emboli. Nobl5 described the same effects after the use of solutions of dextrose varying from 50 to 65 per cent. Since then the treatment of varicose veins by injection has been reported
MONSON LP. TREATMENT OF THE HYPERTROPHIED INFERIOR TURBINATE BY USE OF SCLEROSING SOLUTIONS. Arch Otolaryngol. 1935;22(1):96–98. doi:10.1001/archotol.1935.00640030107008
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