[Skip to Content]
[Skip to Content Landing]
Article
August 1935

NUCLEIC ACID AND NUCLEOTIDE THERAPY IN NASAL DISEASESCONTRIBUTIONS TO THE STUDY OF THE CHEMICAL ASPECTS OF NASAL DISEASES

Arch Otolaryngol. 1935;22(2):172-181. doi:10.1001/archotol.1935.00640030185005
Abstract

Modern chemistry holds many essential building stones for the understanding of the metabolism of mucous membrane, what it produces and what chemical substances are formed in retained secretions, what influences changes of pH have on secreting membranes and, further, what systemic chemical changes manifestly affect the mucous membrane.

Before one proceeds with the chemical study it is important to view the nose and the accessory nasal sinuses anatomically for the biophysical aspects. The cavities of the sinuses are covered by an almost single cell epithelial layer supported by a loose reticular structure and forming an almost dialyzing membrane. There are barely any glands, and such as are present lie close to the orifice of the sinuses. Here is a mechanism for rapid transudation of large volumes of fluid and similarly an area for movement in the opposite direction or absorption. This is independent of the question of

×