The solid constituents of amniotic fluid and the associated cellular exudate so frequently found post mortem in the middle ear of the new-born infant have been regarded as evidence of a condition distinct from otitis media of infancy.1 Opinions as to their nature and significance have been diverse. Zaufal2 thought them a product of spontaneous degeneration of the embryonal mucosa; Aschoff,1b a foreign body reaction, and Hartmann,3 a factor predisposing to secondary infection. Ascending infection of the amniotic fluid in cases of premature rupture of the fetal membranes has long been demonstrated,4 and the association of premature rupture of the membranes with intra-uterine aspiration pneumonia has been shown.5 Infection of the middle ear through the same course of events has been suggested as a possibility,6 but illustrative cases are not found in the literature. A consideration of this factor forms
HEMSATH FA. INTRA-UTERINE AND NEONATAL OTITIS: A STUDY OF SEVEN CASES INCLUDING A CASE OF OTITIC MENINGITIS. Arch Otolaryngol. 1936;23(1):78–92. doi:10.1001/archotol.1936.00640040085008
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: