In the large majority of cases the diagnosis of laryngeal tuberculosis can be adequately made by clinical examination of the larynx with a mirror, provided the examiner has had sufficient clinical experience with this disease. One must remember, however, that in certain circumstances the tuberculous lesion may simulate a neoplasm, either benign or malignant, or may be associated with malignant disease or syphilis or with both. Dworetzky,1 whose opinion is based on twenty years' experience with laryngopulmonary tuberculosis, makes the important point that, as laryngeal involvement is so universally a complication of pulmonary tuberculosis, the diagnosis of laryngeal tuberculosis is rarely justified if after a thorough search an infection of the lungs cannot be found. However, there are cases, with or without a pulmonary lesion, in which a most careful clinical study has failed to clear up the diagnosis, and then the question of biopsy comes up.
WOOD GB. Progress in Otolaryngology: Summaries of the Bibliographic Material Available in the Field of Otolaryngology: LARYNGEAL TUBERCULOSIS. Arch Otolaryngol. 1936;23(2):236–244. doi:10.1001/archotol.1936.00640040243007
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