In the spring of 1931, during investigations of water-soluble extracts of human nasal and sinus mucosa, an exhilarating effect was observed in patients suffering from chronic disease of the sinuses who were given injections of this material. Not only did the local condition improve decidedly, but the patients experienced a feeling of general well-being. In addition, it was noted that the incidence of colds in these patients was markedly reduced. This phenomenon led to the investigation of the material with regard to its possible curative powers.
The material was prepared by grinding freshly obtained human mucosa with sand, allowing it to extract over night in the cold and filtering and concentrating it to about one fifth of its original volume in an air tunnel. It was then passed through a porcelain filter and injected in 1 cc. doses.
Since the amount of material obtainable was limited, it was not possible
FOX N, HARNED JW. USE OF EXTRACT OF NASAL MUCOSA IN TREATMENT OF ACUTE AND CHRONIC RHINOSINUSITIS: A PRELIMINARY REPORT. Arch Otolaryngol. 1936;24(1):89–91. doi:10.1001/archotol.1936.00640050096010
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