It is necessary to trace the development of the morbid changes associated with chronic sinusitis and to follow the clinical behavior of the disease to appreciate its association with the origin and epidemicity of the common cold.
CHRONIC NONINFECTIOUS INFLAMMATION
Allergy and biochemical factors may build in the sinus an edematous, reticulous type of mucosa favorable to subsequent bacterial invasion and their protracted establishment.1
ACUTE INFECTIOUS INFLAMMATION
The True Cold.—Etiology: It is granted that the so-called complications of the common cold are caused by the essential pathogens.2 The fact that a cold can be caused by a filtrable virus does not deny the same etiologic power to the hemolytic streptococcus.
Morbid Anatomy: The changes that take place in the tissues depend on the character of the mucosa at the time of the infection. A normal mucosa independent of allergic or biochemical disturbances reacts differently to
SEWALL EC. CHRONIC SINUSITIS: THE ENDEMIC FOCUS AND CARRIER OF THE COMMON COLD. Arch Otolaryngol. 1936;24(4):413–424. doi:10.1001/archotol.1936.00640050425001
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