The many papers appearing in the literature on the etiology of nasal polypi for the most part are divided into two main schools of thought, one holding that allergic disorder is the primary factor and infection is a secondary factor in the production of polypi, and the other maintaining that the hyperplastic changes are due to a primary bacterial infection. Many earlier investigators thought that a general constitutional predisposition, either acquired or inherited, is responsible for the formation of nasal polypi. The latter view coincides with the more recent observations, which hinge on the allergic origin of edematous polypi. Accepting for the moment that all edematous mucous nasal polypi are of allergic origin and that histamine is involved in the allergic phenomenon, it would appear reasonable to assume that histamine plays a part in the production of polypoid tissue. It was in an attempt to solve this
BUHRMESTER CC, WENNER WF. PRESENCE OF A HISTAMINE-LIKE SUBSTANCE IN NASAL MUCOSA, NASAL POLYPI AND NASAL SECRETION. Arch Otolaryngol. 1936;24(5):570–581. doi:10.1001/archotol.1936.00640050583002
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