In a series of papers beginning in 1919 Mullin1 has repeatedly called attention to the relation between drainage from the paranasal sinuses and certain types of pulmonary infection. He pointed out that particles of india ink or bacteria introduced into the sinuses of cats and rabbits, the sinus membranes being injured to facilitate absorption, are taken up by the lymphatics and find their way to the bronchial and mediastinal lymph nodes. Mullin and Ryder2 reported that the inhalation of suspensions of carbon or of tubercle bacilli by rabbits results in pigmentations or tuberculous lesions similar to those of human tuberculosis, including involvement of bronchial lymph nodes.
Various clinical observers have emphasized one or the other of the possible routes of entry of infectious material to the lungs and the related lymph nodes in relation to bronchitis, bronchiectasis and other pulmonary disturbances. Quinn and Meyer,3 Clerf
LARSELL O, FENTON RA. LYMPHATIC PATHWAYS FROM THE NOSERESEARCH REPORT. Arch Otolaryngol. 1936;24(6):696–713. doi:10.1001/archotol.1936.00640050711002
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