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THEONTOGENETICAPPROACH TO THEPATHOLOGY OFDEAFNESS. DR. LOUIS K. GUGGENHEIM, St. Louis.
Of the various approaches to the pathology of deafness, the embryologic has been the most neglected. The reason seems to be that few otologists understand the ontogenesis of the ear and embryologists are usually not interested in deafness.
An adhesive process or fibrosis of the tympanum was formerly considered to be entirely of inflammatory origin. If it was a sequel of chronic suppuration, it resulted from organization of granulation tissue or from direct differentiation of round cells into fibroblasts and connective tissue. In cases in which there was no suppuration a mild but long-continued round cell infiltration caused the fibrosis. The histologic picture of otosclerosis, accurately described by Politzer over fifty years ago, was accepted as the sole phase of that mysterious malady.
Then came a closer relationship between otolaryngology and general medicine and with it
FRANK I, THEOBALD WH. CHICAGO LARYNGOLOGICAL AND OTOLOGICAL SOCIETY: Regular Monthly Meeting, Oct. 12, 1936. Arch Otolaryngol. 1936;24(6):803–808. doi:10.1001/archotol.1936.00640050818014
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