The ability of the sphenoid bone to defend itself usually prevents the onset of osteomyelitis and tends to limit extension when the bone is invaded. Consequently, a review of medical literature reveals few reported cases. Such cases as are reported appear chiefly in the literature of the last seven years and parallel the careful studies of disease in the base of the skull made by trained clinicians seeking to solve baffling clinical problems by further study of the pathologic anatomy of this region. Since osteomyelitis of the sphenoid bone occasionally occurs, physicians should be prepared to interpret its onset, recognize its symptoms and consider therapeutic possibilities. Insufficient knowledge of disease in this relatively inaccessible region, necropsy permits of restricted character and the actual relative rarity of the condition have contributed to the limitation of case reports.
Eagleton1 commented on infection of the base of the sphenoid as follows:
LAWSON LJ. OSTEOMYELITIS OF THE SPHENOID BONE: A REPORT OF TWO CASES. Arch Otolaryngol. 1937;25(1):1–10. doi:10.1001/archotol.1937.00650010009001
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