Some work has been done on the composition of cigaret smoke and the effect of the various constituents of the smoke on the mucosa of the respiratory tract and on the conjunctival sac. Little investigation has been done on the possible irritative effects of the glycerin or diethylene glycol used as a moistener, or binder, in cigarets on the mucosa exposed to the smoke. Mulinos and Osborne1 found the smoke from cigarets moistened with glycerin more irritating to the conjunctival sac of rabbits than that from those in which diethylene glycol was used, or from those in which no hygroscopic agent was employed. A mechanical smoker was used, in which the smoke was passed through water. Two or three drops of this water was instilled into the conjunctival sac of rabbits. The irritation was determined by the degree of edema produced. Flinn,2 in a clinical investigation on human subjects, obtained
BALLENGER HC, JOHNSON VH. EFFECTS ON THE THROAT AND CONJUNCTIVA OF THE HYGROSCOPIC AGENT USED IN CIGARETS. Arch Otolaryngol. 1937;25(1):75–80. doi:10.1001/archotol.1937.00650010083010
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