Lillie1 in 1925 reviewed the literature on osteomyelitis of the cranial bones secondary to operations on the paranasal sinuses and reported two cases, including the observations at necropsy.
Bulson2 in 1925 reviewed the reports of cases of osteomyelitis of the skull as a complication of frontal sinusitis which had appeared in the literature for the previous thirty years. He collected reports of fifty-five cases, with thirty-seven deaths, a mortality of 67 per cent. Further analysis of Bulson's statistics revealed twenty-eight cases of complicated chronic frontal sinusitis with a mortality of 75 per cent, and twenty-seven cases of complicated acute frontal sinusitis with a mortality of 60 per cent; twenty-six patients had osteomyelitis previous to the first operation.
In regard to the bacteria present, he reported one case in which pneumococci were found but the patient recovered, five in which streptococci were isolated and all the patients died and fourteen in
WILLIAMS HL, HEILMAN FR. SPREADING OSTEOMYELITIS OF THE FRONTAL BONE SECONDARY TO DISEASE OF THE FRONTAL SINUS: WITH A PRELIMINARY REPORT AS TO BACTERIOLOGY AND SPECIFIC TREATMENT. Arch Otolaryngol. 1937;25(2):196–207. doi:10.1001/archotol.1937.00650010218008
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