The failure to recognize a disease is usually due to inexperience with it or to lack of knowledge of its existence. Intranasal polypoid inflammatory growths are so common and their association with non-specific types of chronic rhinitis is so generally accepted that usually they receive only routine attention and are rarely submitted for histologic examination.
The association of a specific etiologic agent with certain types of nasal polyps was demonstrated independently by Seeber1 and by O'Kinealy.2 The agent in question is Rhinosporidium seeberi, or Rhinosporidium kinealyi. Prior to the report of 60 cases by Allen and Dave3 only 54 cases had been described in the literature. These were from widely separated parts of the world. The disease is probably by no means so rare as these figures would indicate, for several observers refer to groups of cases encountered by them and by others but not published.
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PASTERNACK JG, ALEXANDER CS. RHINOSPORIDIUM SEEBERI: AN ETIOLOGIC AGENT IN THE PRODUCTION OF NASAL POLYPS. Arch Otolaryngol. 1938;27(6):746–765. doi:10.1001/archotol.1938.00650030764006
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