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One cannot approach this work, published after Dr. Gray's death from somewhat incomplete manuscript and notes, without the respect due a brilliant author whose works on "The Ear and Its Diseases," "Otosclerosis" and "The Labyrinth of Animals," have secured international honor. While one may be somewhat skeptical of the ultimate success of his dictum on the treatment of tinnitus and otosclerosis with thyroxin, this scholarly otologist must command attention.
His hypothesis of the origin of tissue is based on the belief that change of environment causes injury and subsequent repair to a given tissue or structure and that a new type of tissue follows this process of repair. In discussing the developmental aspect of the evolution of tissue and pathogenesis, he is of the opinion that induced variation, change in tissue brought about by injury from change in environment, rather than spontaneous variation, an evolution due to an accumulation of
The Basis of Tissue Evolution and Pathogenesis. Arch Otolaryngol. 1938;28(1):151. doi:10.1001/archotol.1938.00650040158012
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