Since the time of Hippocrates medical literature has contained many notes concerning the intimate relationship existing between the nose and the generative system. The first extensive and accurate observations of the phenomenon were presented by John Noland Mackenzie,1 a Baltimore surgeon, in 1884. Three years later Fliess2 noted similar nasogenital relationships. He developed a therapeutic technic of cocainization of the "genital spots" in the nose for the alleviation of menstrual dysfunctions. In the United States, Brettauer3 in 1911 reported good results in a large series of cases of dysmenorrhea in which the condition was treated by cocainization and cauterization of the nose. Seifert4 made a critical study of the literature and cited 300 publications concerning the nasogenital relationship. For some time after these studies appeared, interest in this phenomenon dwindled; recently, however, it has been revived.5
Mortimer and his associates from the Montreal General Hospital investigated the nasal mucosa of
ROSEN S. THE NASOGENITAL RELATIONSHIP. Arch Otolaryngol. 1938;28(4):556–560. doi:10.1001/archotol.1938.00650040567005
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