From the time of its description by Fallopius, in 1561, to the publication of Max Schaeffer's paper on diagnosis and treatment, in 1890, interest in the sphenoid sinus was largely centered on the anatomy and pathology. The dictum of Hyrtl that "Die Keilbeinhöhle ist ganz ausser dem bereiche chirurgische Angriffe" (The sphenoid sinus is entirely outside the domain of surgical attack) was universally accepted.
Although Cavanaugh and others said they believed that the first known case of disease of the sphenoid sinus was that described by Rouge, in 1871, investigation has revealed several earlier reports. The earliest one of which I am aware was that of Lieutaud, in 1735. The patient was supposed to have had pulmonary suppuration, but autopsy revealed a purulent disorder of the maxillary, frontal and sphenoid sinuses.
A report published in 1810 by Leveque-Lasource concerned a woman 38 years of age. She complained of headache, anorexia
TEED RW. MENINGITIS FROM THE SPHENOID SINUS. Arch Otolaryngol. 1938;28(4):589–619. doi:10.1001/archotol.1938.00650040600009
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