No acute infectious disease has ever been studied with greater intensity than acute anterior poliomyelitis, and yet, despite the great accumulation of experimental data, no positive method of prevention and no promising method of treatment has thus far been found. While this paper deals primarily with the application of chemicals to the olfactory nerves as a preventive measure against the disease, it is of interest to review some of the history and the experimental data which may lead to success in this method of prophylactic treatment.
Poliomyelitis has been a recognized entity since Joerg1 described it in 1816. Heine, between the years 1840 and 1860, collected cases of a definite type from the records of paralysis of children and raised this type, the flaccid, atrophic spinal type, to a definite clinical entity. Medin, by 1890, had founded the symptomatology of the disease, and Wickman, by his clinical studies and his