Since the advent of sulfanilamide, an increasing number of cases of hemolytic streptococcic meningitis with recovery have been reported. We feel that such cases, however, are of sufficient interest and significance to justify adding this present case to the series.
Gray,1 in a comprehensive review of the literature, listed 66 cases of streptococcic meningitis with recovery in the period from 1901 to 1935. Trachsler2 found 39 additional instances of recovery in the short interval following the introduction of sulfanilamide; he reported 5 original cases.
The experimental work of Domagk3 and later of Long4 showed the value of chemotherapy in the treatment of streptococcic infections and provided an impetus for much of the later work. Long found little evidence that sulfanilamide was bactericidal; however, bacteriostasis of hemolytic streptococci was found to occur in mediums containing sulfanilamide. The action of the drug has been considered primarily one of slowing down the rate
GONNE WS, MICHELS MW, WATSON T. RECOVERY FROM HEMOLYTIC STREPTOCOCCIC MENINGITIS OF OTITIC ORIGIN. Arch Otolaryngol. 1939;29(2):382–387. doi:10.1001/archotol.1939.00650050402017
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