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Article
May 1939

TREATMENT OF DEAFNESS AND CONTIGUOUS NERVOUS DISORDERS WITH PROSTIGMINE: A PRELIMINARY CLINICAL REPORT

Arch Otolaryngol. 1939;29(5):751-758. doi:10.1001/archotol.1939.00650050813001
Abstract

Many interesting and informative reports on the use of prostigmine in the diagnosis and treatment of myasthenia gravis are being published. The effect of this drug on the nerves supplying the facial tissues has been fairly well studied. Yet it seems strange that the effect of the drug on the ear has not been noticed by those using the remedy in other conditions.

Our study of prostigmine began with a personal experiment by one of us (Dr. Rommel). In October 1936 he hypodermically injected 1 cc. of prostigmine prophylactic (1:4,000 solution) into himself in an experiment to learn something about the reactions of the tissues to this complex chemical. He found that it made his sense of hearing much more acute. A bedroom tickless clock, which makes no louder sound than a watch, became audible at a distance of 8 feet (245 cm.). This, he thought, is something deserving further

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