In Schenck's review of the literature on the use of sulfanilamide1 it was stated (page 746) that there is a singular paucity of reports concerning the effects of sulfanilamide on infection of the sinuses. I have used the drug in cases of pharyngitis, tonsillitis, sinusitis, otitis media and erysipelas since March 1937,2 and have used prontosil, now neoprontosil,3 locally in the antrum since February 1938,4 with excellent results.
Since nine months ago, when a surprising resolution of intractable purulent maxillary sinusitis followed instillation of neoprontosil,4 it has been almost routine practice in the institution with which I am associated to treat that condition by this method. At first smears and cultures were made and the use of the dye limited to antrums from which streptococci were isolated, but in others, from which Pneumococcus type III was isolated, good results followed, and now it is used all purulent maxillary sinusitis for
CHILDREY JH. USE OF SULFANILAMIDE LOCALLY FOR SINAL INFECTION. Arch Otolaryngol. 1939;29(6):986–987. doi:10.1001/archotol.1939.00650051066011
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