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Article
March 1940

PROBABLE PATHOGENIC STREPTOCOCCI AND STAPHYLOCOCCI IN CHRONIC LOW GRADE ILLNESS: AN ANALYSIS OF THEIR FREQUENCY IN THREE HUNDRED AND NINETY-FIVE CASES

Author Affiliations

Associate Physician, Chestnut Hill Hospital, and Assistant Physician, Germantown Dispensary and Hospital PHILADELPHIA; Director, Clinical Research Laboratory NEW YORK

Arch Otolaryngol. 1940;31(3):458-466. doi:10.1001/archotol.1940.00660010462008
Abstract

Recently described in vitro tests of bacteria1 have been shown to give results parallel with certain pathogenic properties of the cultures and with other biologic findings.10 Although cultures reacting positively to these tests are probably pathogenic,10 for clarity they will be referred to as "in vitro positive" rather than "probable pathogenic." The development of these tests has made possible the study of the relation of large numbers of staphylococci and streptococci associated with chronic, and sometimes with acute, illnesses. In the investigation to be discussed the methods were used in the study of the distribution of probable pathogenic staphylococci and streptococci in patients with low grade chronic illness. Observations on the distribution of the sedimentation rates and nonfilament-filament ratios of 292 of these patients have been reported.2

MATERIAL  Of the 395 patients studied, most of them showed more than one disease, 96.3 per cent had clinical evidence of involvement of

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