The status of sulfanilamide as a chemotherapeutic agent in the conservative treatment of infection of the middle ear and of the mastoid is still in question.
It seems a well established fact that the earlier the drug is employed in the treatment of this type of infection, the better are the results. This has been physiologically explained on the basis of the more accessible contact of the drug with body fluids in the early stages.1 However, Long and Bliss, after their most recent experiments with the clinical use of sulfanilamide for human infections, have stated: "Sulfanilamide can be found in about the same concentration as it exists in the blood in transudates and exudates into all the body cavities. It also penetrates into the pus in closed abscesses and is present in purulent discharges."1a
This thesis presents a study of 17 patients with purulent aural infection treated with sulfanilamide who
HEBBLE HM. SULFANILAMIDE IN TREATMENT OF ACUTE INFECTION OF THE EAR AND OF THE MASTOID IN INFANTS AND IN CHILDREN: QUANTITATIVE STUDY OF SEVENTEEN CASES. Arch Otolaryngol. 1940;31(5):808–818. doi:10.1001/archotol.1940.00660010822003
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