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Article
August 1940

INTRADURAL CONDITIONS IN RELATION TO RHINOLOGY AND OTOLOGY: CRITICAL SURVEY OF RECENT LITERATURE

Author Affiliations

NEWARK, N. J.

Arch Otolaryngol. 1940;32(2):256-298. doi:10.1001/archotol.1940.00660020259005
Abstract

TREATMENT OF MENINGITIS 

EXPERIMENTAL WORK ON THE CURE OF MENINGITIS  Experiments with Horse Serum.—Burtenshaw134 attempted to ascertain what proportion of the serum which had been administered parenterally to patients suffering from meningococcic meningitis in reality reached the cerebrospinal fluid.Antitoxin Precipitin Reaction: For this purpose he used an adaptation of the precipitin reaction for the presence of antitoxincontaining horse serum in the body fluids. Twenty-three patients with meningococcic meningitis and 1 patient from whom only a strain of staphylococcus could be isolated were used. Each received meningococcus antitoxin by intravenous injection. Horse serum protein was detected in the cerebrospinal fluid in every case, though its concentration varied greatly and was always small compared with that in the blood.Burtenshaw stated (1) that intrameningeal injections of serum insure the immediate presence of large amounts of antibody at the site of infection; and yet (2) that the steepness of the drop in

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