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Article
September 1940

CERTAIN REACTIONS OF LARYNGEAL TISSUES TO MEDICINAL AGENTS

Author Affiliations

PORTLAND, ORE.
From the Departments of Otolaryngology and Anatomy, University of Oregon Medical School.

Arch Otolaryngol. 1940;32(3):429-433. doi:10.1001/archotol.1940.00660020433002
Abstract

Reactions of laryngeal tissues to various medicaments have apparently, so far as various authoritative writers are concerned, been assumed from observation of clinical effects and from the gross behavior and histologic appearance of more accessible tissues in the nose, mouth and pharynx. It is of course a commonplace among laryngologists that tissues above the epiglottis are definitely more resistant to local trauma than are the mucosal and submucosal structures of the larynx itself.

It was thought desirable, therefore, to expose the glottis in young cats anesthetized by pentobarbital sodium administered intraperitoneally; a small Jackson laryngoscope was used, and the posterior surface of the epiglottis and upper aspect of the larynx were gently swabbed with various therapeutic solutions not uncommonly used. Irritation by respiratory anesthesia was thus entirely avoided. Within twenty-four hours these animals were killed by section of the cervical portion of the cord or by an overdose of pentobarbital

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