Neoplasms of the upper end of the respiratory tree (the nasal cavities, mouth, pharynx and hypopharynx) are more common than in any other region of the body. This is due undoubtedly to the multiplicity of folding and infolding of the neural tube during embryonal development, the numerous and varied types of bacteria which infest these cavities and the traumatism, chemical, thermal and other, to which this part of the structure is so frequently subjected. Often the diagnosis is not made until metastases have become so extensive that therapeutic measures are hopeless. Report by the pathologist of carcinoma without accurate description of the type is misleading and usually results in the otolaryngologist figuratively "throwing up his hands and quitting." Hopeless as the fight against carcinoma at present seems to be, progress can be made and some lives perhaps prolonged only by accurate determination of the type of cell which is producing
CLOWARD RE. NASOPHARYNGEAL CANCER. Arch Otolaryngol. 1940;32(3):512–516. doi:https://doi.org/10.1001/archotol.1940.00660020516009
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